Synthesis of fatty acids using organocopper (I) ate complexes derived from Grignard reagents.
نویسندگان
چکیده
Fatty acid esters have been synthesized in good yield by reaction between copper(I) ate complexes formed from methylcopper(I) and primary or secondary Grignard reagents and esters of primary iodoalkylcarboxylic acids. The synthetic method is i l lustrated with proced.ures for CHr:gH(CHz)rgCO2C2H5, CeHsCHzO(CH2)16COzCzHs, CH3(CH2)25CO2C2H5, CH3O2C(CH)I2CO2CHI, CzHsOzC(CHz)szCO2C2H5, and CHg(CH2)4CH(CHs)(CHz)roCOzCHs. The reaction sequence uses starting Grignard reagent with high efficiency, provides product mixtures that are conveniently worked up, and tolerates a variety of functional groups. It provides the most direct route presently available to a variety of representative classes of simple fatty acids.
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عنوان ژورنال:
- The Journal of organic chemistry
دوره 40 6 شماره
صفحات -
تاریخ انتشار 1975